|
rs12122803
|
C1orf112
|
Venous Thromboembolism
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism.
|
31420334 |
2019 |
|
rs185120584
|
C1orf112
|
Venous Thromboembolism
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism.
|
31420334 |
2019 |
|
rs1458766475
|
SELE;C1orf112
|
Venous Thromboembolism
|
|
0.010 |
GeneticVariation |
BEFREE |
Homozygosity for the S128R E-selectin allele appears to increase the risk for recurrent VTE several fold.
|
16908800 |
2006 |
|
rs5361
|
SELE;C1orf112
|
Venous Thromboembolism
|
|
0.010 |
GeneticVariation |
BEFREE |
Homozygosity for the S128R E-selectin allele appears to increase the risk for recurrent VTE several fold.
|
16908800 |
2006 |
|
rs12938
|
SELL;C1orf112
|
Vascular Diseases
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified increased levels of soluble L-selectin (sL-selectin), but not soluble E-selectin (sE-selectin) in 278 European-Caucasian lupus patients compared to 230 healthy siblings (P=0.002). sL-selectin levels were markedly elevated in patients with IgG antiphospholipid autoantibodies (P=0.002), suggesting that perhaps sL-selectin defines a subgroup of lupus with vasculopathy. sL-selectin level was also influenced by two L-selectin polymorphisms: 665C>T, F206L in the epidermal growth factor-like domain (P=0.015) and rs12938 in the 3'-untranslated region (P=0.06).
|
15902275 |
2005 |
|
rs1131498
|
SELL;C1orf112
|
Ulcerative Colitis
|
|
0.010 |
GeneticVariation |
BEFREE |
Subgroup analysis showed that the L206 allele and F/L206 genotype frequencies were significantly increased in UC patients with left-sided type; whereas, the F/L206 genotype was significant in CD patients with ileocolonic location and stricturing behavior compared with controls.
|
19212205 |
2009 |
|
rs5355
|
SELE;C1orf112
|
Ulcerative Colitis
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigate seven mutations in CAM: G241R and K469E in ICAM-1, V125L in PECAM-1, G98T, S128R, and L554F in E-selectin and F206L in L-selectin in 197 Tunisian patients (73 with UC and 124 with CD) and 194 controls.
|
19212205 |
2009 |
|
rs3917412
|
SELE;C1orf112
|
Tumor Cell Invasion
|
|
0.010 |
GeneticVariation |
BEFREE |
The combination of the selectin E (SELE) rs3917412 G>A G/G and the methylentetrahydrofolate reductase (MTHFR) rs1801133 T/T genotypes was associated with a significantly increased risk for recurrence in both the training [RR = 4.103; 95% confidence interval (CI), 1.803-9.334; P = 0.001] and the validation cohorts (RR = 3.567; 95% CI, 1.253-10.151; P = 0.017) in the multiple regression analysis considering the stage, lymphovascular invasion, and bowel perforation as covariates.
|
24980946 |
2014 |
|
rs1131498
|
SELL;C1orf112
|
Tuberculosis
|
|
0.010 |
GeneticVariation |
BEFREE |
Based on the findings, the incidence of TB and L-selectin polymorphism in the Phe206Leu gene had no significant association.
|
29430726 |
2018 |
|
rs5361
|
SELE;C1orf112
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
The E-selectin S128R C allele may confer an increased susceptibility to gastric cancer development and correlate with a poor prognosis.
|
23015400 |
2013 |
|
rs5361
|
SELE;C1orf112
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
We concluded E-selectin variant rs5361 and FCGR2A variant rs1801274 were significantly associated with gastric cancer risk.
|
21780194 |
2012 |
|
rs1458766475
|
SELE;C1orf112
|
Stomach Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
The E-selectin S128R C allele may confer an increased susceptibility to gastric cancer development and correlate with a poor prognosis.
|
23015400 |
2013 |
|
rs3917412
|
SELE;C1orf112
|
stage, colon cancer
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings suggest that the SELE rs3917412 and MTHFR rs1801133 SNPs could serve as pharmacogenetic predictors of tumor recurrence in patients with early-stage colon cancer treated with oxaliplatin-based adjuvant chemotherapy, thus allowing personalized selection of treatment to optimize clinical outcomes.
|
24980946 |
2014 |
|
rs1458766475
|
SELE;C1orf112
|
Simple renal cyst
|
|
0.010 |
GeneticVariation |
BEFREE |
The role of serum E-selectin level and E-selectin gene S128R polymorphism on the enlargement of renal cyst in patients with polycystic kidney disease: Genetic background of renal cyst growth
.
|
31746731 |
2020 |
|
rs5361
|
SELE;C1orf112
|
Simple renal cyst
|
|
0.010 |
GeneticVariation |
BEFREE |
The role of serum E-selectin level and E-selectin gene S128R polymorphism on the enlargement of renal cyst in patients with polycystic kidney disease: Genetic background of renal cyst growth
.
|
31746731 |
2020 |
|
rs1458766475
|
SELE;C1orf112
|
Secondary Neoplasm
|
|
0.010 |
GeneticVariation |
BEFREE |
We postulated that some polymorphisms within the E-selectin gene, especially the S128R polymorphism, may increase the risk of metastases by facilitating adhesion of tumour cells to the endothelium.
|
19361981 |
2009 |
|
rs5361
|
SELE;C1orf112
|
Secondary Neoplasm
|
|
0.010 |
GeneticVariation |
BEFREE |
We postulated that some polymorphisms within the E-selectin gene, especially the S128R polymorphism, may increase the risk of metastases by facilitating adhesion of tumour cells to the endothelium.
|
19361981 |
2009 |
|
rs1458766475
|
SELE;C1orf112
|
Renal cyst
|
|
0.010 |
GeneticVariation |
BEFREE |
The role of serum E-selectin level and E-selectin gene S128R polymorphism on the enlargement of renal cyst in patients with polycystic kidney disease: Genetic background of renal cyst growth
.
|
31746731 |
2020 |
|
rs5361
|
SELE;C1orf112
|
Renal cyst
|
|
0.010 |
GeneticVariation |
BEFREE |
The role of serum E-selectin level and E-selectin gene S128R polymorphism on the enlargement of renal cyst in patients with polycystic kidney disease: Genetic background of renal cyst growth
.
|
31746731 |
2020 |
|
rs3917412
|
SELE;C1orf112
|
Recurrent tumor
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings suggest that the SELE rs3917412 and MTHFR rs1801133 SNPs could serve as pharmacogenetic predictors of tumor recurrence in patients with early-stage colon cancer treated with oxaliplatin-based adjuvant chemotherapy, thus allowing personalized selection of treatment to optimize clinical outcomes.
|
24980946 |
2014 |
|
rs1805193
|
SELE;C1orf112
|
Recurrent aphthous ulcer
|
|
0.010 |
GeneticVariation |
BEFREE |
There was a significant association of the A allele (Pcorr = 0.027), AA and AC genotypes (OR = 10.9 and 9.0, respectively) of the E-selectin rs5361 gene polymorphism and TAA haplotype (rs2205849, rs5361, and rs1805193, respectively; P = 0.03) with RAS.
|
23772946 |
2013 |
|
rs5361
|
SELE;C1orf112
|
Recurrent aphthous ulcer
|
|
0.010 |
GeneticVariation |
BEFREE |
This is the first report to link inheritance of the A allele, AA and AC genotypes of the E-selectin rs5361 polymorphism with increased risk of RAS.
|
23772946 |
2013 |
|
rs1458766475
|
SELE;C1orf112
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation |
BEFREE |
Our meta-analysis revealed that there was association between the E-selectin S128R polymorphism and the risk of cancer.
|
24815478 |
2014 |
|
rs1458766475
|
SELE;C1orf112
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation |
BEFREE |
E-selectin S128R "C" allele may confer an increased susceptibility to pancreatic cancer development, while its carriage status does not appear to be related to the aggressive features of this malignancy.
|
20607758 |
2010 |
|
rs5361
|
SELE;C1orf112
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation |
BEFREE |
E-selectin S128R "C" allele may confer an increased susceptibility to pancreatic cancer development, while its carriage status does not appear to be related to the aggressive features of this malignancy.
|
20607758 |
2010 |